Stillste Stund & other

Saturday, 6 September 2008

Temozolomide And Thalidomide Combination Effective Against Malignant Melanoma Spread To CNS And White Blood Cell Count May Be Prognostic

�Researchers at the Odense University Hospital, Denmark, have found that combining thalidomide with temozolomide may duple its effectuality, over temozolomide alone, for malignant melanoma with brain metastases.

The non-randomised phase II test, published in the on-line journal ecancermedicalscience, investigated the combination of thalidomide and temozolomide. It is the first phase II survey combining a new cyclic regimen of temozolomide (150mg /m2 casual, 7 years on 7days off) and thalidomide, for patients with malignant melanoma suffering from brain metastases, to show a meaningful response pace.

Melanoma is the third most common cause of metastases in the primal nervous system. Thalidomide is known to prevent new blood vessels growing from pre-existing vessels and thus inhibit neoplasm growth, and is besides known to adjust the body's immune response. Temozolomide is a chemotherapy alkylating agent ordinarily used for primary brainiac tumours, only also alive in melanoma.

The researchers observed a response charge per unit of 17.5% for temozolomide and thalidomide combined, around double the response rate of the standard schedule of temozolomide alone (6-9% naturalized in a previous study).

A statistically significant correlation was found between efficaciousness and lymphopenia (lowered white blood cell count).

Lead author Dr Lene Vestermark concluded: "The combination of temozolomide using the dose-intense schedule and thalidomide at 100-200 mg/day is a safe regimen leading to clinical efficacy in patients with brain metastases from malignant malignant melanoma.

Most importantly it seems that patients who develop lymphopenia during therapy make a higher chance of obtaining objective response. The potential immunological mechanism behind this will be the subject of future investigations, focusing on the potential difference benefit of regulatory T Cell down-regulation. The correlation between lymphocytopenia and documentary response necessarily further investigation."

Further evaluations using larger patient numbers racket and including different therapy schedules will be considered for the future.

Temozolomide also known as Temodal or Thalomid

http://www.ecancermedicalscience.com

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Wednesday, 27 August 2008

Applegate and other high-risk women act fast against cancer

Christina Applegate's choice to undergo a double mastectomy puts her in the company of a ontogenesis number of women taking aggressive steps to avoid dying of breast cancer.

Studies show more patients are choosing mastectomies, even though women are just as likely to survive if they have smaller, breast-conserving surgeries.

Tuesday that she had early-stage cancer in only one breast and underwent deuce lumpectomies. Second surgeries aren't uncommon. Up to 25% of women who take lumpectomies demand a second base surgery to remove extra cancerous tissue, says Isabelle Bedrosian of Houston's M.D. Anderson Cancer Center.

, for example, plant 18% of women with the mutations took this approach. More than half the women had their ovaries removed, which reduces the risk of exposure of both breast and ovarian cancers by removing the body's major source of estrogen.

Other women decide to undergo frequent screening with MRIs, or magneitc resonance imaging, instead of preventive operating theatre, says David Johnson of the Vanderbilt-Ingram Cancer Center in Nashville.

Doctors don't recommend MRIs for all women, says Minetta Liu, a chest cancer medical specialist at Georgetown's Lombardi Comprehensive Cancer Center. For most women, doctors advise getting a yearbook mammogram beginning at age 40.

Liu says insurance normally covers MRIs for women at high risk: those with a close congenator with chest cancer, such as a mother or sister; those with one of the genetic mutations; or those whose danger of breast cancer is more than 20%, based on a rating system called the Gail model.

While MRIs ar far more sensitive than mammograms, they also increase the risk of exposure that a woman will have a mastectomy, according a study from the Mayo Clinic.

Mayo researchers found that breast cancer patients who underwent MRIs were more likely than others to have a bosom removed instead of a lumpectomy. That may be because MRIs are more likely to pick up second tumors in women who are already scheduled for oR, Liu says.

In fact, in 16% of cases, MRIs find extra cancer in the affected breast. And in about 3% of cases, the MRI finds cancer in the diametrical breast, says Julie Gralow, a breast cancer technical at the University of Washington.

Growing numbers game of women are opting for double mastectomies, level when they have cancer only in one � even when they lack the risk of infection factors of women like Applegate. Among women with cancer in one chest, the peril of development a tumour in the other breast is less than 1% a year, says Isabelle Bedrosian of Houston's M.D. Anderson Cancer Center.

In 2003, 11% of women having a mastectomy in one breast opted to have surgeons off their unaffected breast, as well, according to a study of 152,755 patients published last yr in the Journal of Clinical Oncology. That's more than double the rate in 1998.

"Women are under the misconception that taking the other breast will keep them from getting breast cancer," Bedrosian says. "But taking the other breast has no impingement on survival from the original cancer."

Bedrosian notes that breast genus Cancer patients rump reduce their risk of a return without surgical operation by taking hormone therapy.

Liu notes that mastectomy crataegus oxycantha seem more attractive today because of improvements in reconstructive surgery.

Women have several reconstructive options, which lav be performed at the time of mastectomy, Golshan says. Insurance generally covers the procedures.

Doctors can restore the breast using a flap of skin from the stomach, back or buttocks, or with silicone or saline solution implants, Golshan says.

READERS: What would you do? Leave your comments below.

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Sunday, 17 August 2008

Download Jim Lauderdale mp3

Artist: Jim Lauderdale: mp3 download

   Genre(s):

Country

Discography:

Country Super Hits, Vol. 1

Year: 2006

Tracks: 13

Bluegrass

Year: 2006

Tracks: 13

Singer/songwriter Jim Lauderdale helped put down out the design for the Americana trend of the '90s, earning high school critical marks for an eclectic serial of albums that spanned hard land, slick pop, rootsy rock music & cast, blues, tribe, R&B, and blue grass. He ne'er sold that many records on his own, merely his compositions were recorded -- ofttimes with considerable success -- by a number of contemporary area stars, including George Strait, Patty Loveless, Vince Gill, Mark Chesnutt, Kathy Mattea, and George Jones, among others. Lauderdale was born in Statesville, NC, in 1957 and grew up loving country euphony; even so, he was besides careworn to the theatre and later stirred to New York, where he landed roles in deuce national touring productions. He later settled in Los Angeles, where he began playing the now-legendary alt-country hot spot the Palomino Club. With Dwight Yoakam producer Pete Anderson behind the boards, he recorded a track for the seminal compilation A Town South of Bakersfield, which helped him -- briefly -- res publica a record deal with CBS. He completed an album in 1989, just the label declined to release it; it last appeared o'er decade long time later on on an overseas label as Point of No Return.Undaunted, Lauderdale signed with the Bluewater euphony publication firm in Nashville, where his compositions set up immediate success in the contemporaneous res publica worldly concern. Additionally, he sang backup on records by Yoakam, Lucinda Williams, and Rosie Flores and toured with everyone from Freedy Johnston, Nick Lowe, and Hootie & the Blowfish to Johnny Cash and Merle Haggard. He earned another shot with Reprise and issued his debut album, Major planet of Love, in 1991, with production from Rodney Crowell and John Leventhal. The record album was greeted with stiff reviews by many critics, world Health Organization hailed Lauderdale as a major modern natural endowment. Still, it would be triplet days before he would release another record; he returned in 1994, now on Atlantic, and issued 2 acclaimed albums over the next iI old age in Pretty Close to the Truth and Every Second Counts. In 1996, he affected over to roots label Rounder's Upstart subsidiary for Persimmons, withal some other critical success.

Hopping to BNA, Lauderdale released Whispering in 1998, then returned to the big league on RCA, issuing the somewhat slicker-sounding, more than commercial Forward Through It All in 1999. That same class, Lauderdale also took a detour into traditional bluegrass, recording the collaborative record album I Feel Like Singing Today with the legendary Ralph Stanley for Rebel. Lauderdale eventually establish a more than permanent home on Dualtone and debuted with 2000's The Other Sessions, a retrovert to hard-core state. 2002 brought iI projects: another album with Stanley, called Lost in the Lonesome Pines, and a country record called The Hummingbirds. Ever prolific, Lauderdale released Hold back Til Spring in 2003, Headed for the Hills in 2004, Bluegrass Region in 2006, and The Bluegrass Diaries in 2007.

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