�Researchers at the Odense University Hospital, Denmark, have found that combining thalidomide with temozolomide may duple its effectuality, over temozolomide alone, for malignant melanoma with brain metastases.
The non-randomised phase II test, published in the on-line journal ecancermedicalscience, investigated the combination of thalidomide and temozolomide. It is the first phase II survey combining a new cyclic regimen of temozolomide (150mg /m2 casual, 7 years on 7days off) and thalidomide, for patients with malignant melanoma suffering from brain metastases, to show a meaningful response pace.
Melanoma is the third most common cause of metastases in the primal nervous system. Thalidomide is known to prevent new blood vessels growing from pre-existing vessels and thus inhibit neoplasm growth, and is besides known to adjust the body's immune response. Temozolomide is a chemotherapy alkylating agent ordinarily used for primary brainiac tumours, only also alive in melanoma.
The researchers observed a response charge per unit of 17.5% for temozolomide and thalidomide combined, around double the response rate of the standard schedule of temozolomide alone (6-9% naturalized in a previous study).
A statistically significant correlation was found between efficaciousness and lymphopenia (lowered white blood cell count).
Lead author Dr Lene Vestermark concluded: "The combination of temozolomide using the dose-intense schedule and thalidomide at 100-200 mg/day is a safe regimen leading to clinical efficacy in patients with brain metastases from malignant malignant melanoma.
Most importantly it seems that patients who develop lymphopenia during therapy make a higher chance of obtaining objective response. The potential immunological mechanism behind this will be the subject of future investigations, focusing on the potential difference benefit of regulatory T Cell down-regulation. The correlation between lymphocytopenia and documentary response necessarily further investigation."
Further evaluations using larger patient numbers racket and including different therapy schedules will be considered for the future.
Temozolomide also known as Temodal or Thalomid
http://www.ecancermedicalscience.com
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Saturday 6 September 2008
Wednesday 27 August 2008
Applegate and other high-risk women act fast against cancer
Christina Applegate's choice to undergo a double mastectomy puts her in the company of a ontogenesis number of women taking aggressive steps to avoid dying of breast cancer.
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Studies show more patients are choosing mastectomies, even though women are just as likely to survive if they have smaller, breast-conserving surgeries.
Tuesday that she had early-stage cancer in only one breast and underwent deuce lumpectomies. Second surgeries aren't uncommon. Up to 25% of women who take lumpectomies demand a second base surgery to remove extra cancerous tissue, says Isabelle Bedrosian of Houston's M.D. Anderson Cancer Center.
, for example, plant 18% of women with the mutations took this approach. More than half the women had their ovaries removed, which reduces the risk of exposure of both breast and ovarian cancers by removing the body's major source of estrogen.
Other women decide to undergo frequent screening with MRIs, or magneitc resonance imaging, instead of preventive operating theatre, says David Johnson of the Vanderbilt-Ingram Cancer Center in Nashville.
Doctors don't recommend MRIs for all women, says Minetta Liu, a chest cancer medical specialist at Georgetown's Lombardi Comprehensive Cancer Center. For most women, doctors advise getting a yearbook mammogram beginning at age 40.
Liu says insurance normally covers MRIs for women at high risk: those with a close congenator with chest cancer, such as a mother or sister; those with one of the genetic mutations; or those whose danger of breast cancer is more than 20%, based on a rating system called the Gail model.
While MRIs ar far more sensitive than mammograms, they also increase the risk of exposure that a woman will have a mastectomy, according a study from the Mayo Clinic.
Mayo researchers found that breast cancer patients who underwent MRIs were more likely than others to have a bosom removed instead of a lumpectomy. That may be because MRIs are more likely to pick up second tumors in women who are already scheduled for oR, Liu says.
In fact, in 16% of cases, MRIs find extra cancer in the affected breast. And in about 3% of cases, the MRI finds cancer in the diametrical breast, says Julie Gralow, a breast cancer technical at the University of Washington.
Growing numbers game of women are opting for double mastectomies, level when they have cancer only in one � even when they lack the risk of infection factors of women like Applegate. Among women with cancer in one chest, the peril of development a tumour in the other breast is less than 1% a year, says Isabelle Bedrosian of Houston's M.D. Anderson Cancer Center.
In 2003, 11% of women having a mastectomy in one breast opted to have surgeons off their unaffected breast, as well, according to a study of 152,755 patients published last yr in the Journal of Clinical Oncology. That's more than double the rate in 1998.
"Women are under the misconception that taking the other breast will keep them from getting breast cancer," Bedrosian says. "But taking the other breast has no impingement on survival from the original cancer."
Bedrosian notes that breast genus Cancer patients rump reduce their risk of a return without surgical operation by taking hormone therapy.
Liu notes that mastectomy crataegus oxycantha seem more attractive today because of improvements in reconstructive surgery.
Women have several reconstructive options, which lav be performed at the time of mastectomy, Golshan says. Insurance generally covers the procedures.
Doctors can restore the breast using a flap of skin from the stomach, back or buttocks, or with silicone or saline solution implants, Golshan says.
READERS: What would you do? Leave your comments below.
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Sunday 17 August 2008
Download Jim Lauderdale mp3
 Artist: Jim Lauderdale: mp3 download Genre(s): Country Discography:  Country Super Hits, Vol. 1 Year: 2006 Tracks: 13  Bluegrass Year: 2006 Tracks: 13 Singer/songwriter Jim Lauderdale helped put down out the design for the Americana trend of the '90s, earning high school critical marks for an eclectic serial of albums that spanned hard land, slick pop, rootsy rock music & cast, blues, tribe, R&B, and blue grass. He ne'er sold that many records on his own, merely his compositions were recorded -- ofttimes with considerable success -- by a number of contemporary area stars, including George Strait, Patty Loveless, Vince Gill, Mark Chesnutt, Kathy Mattea, and George Jones, among others. Lauderdale was born in Statesville, NC, in 1957 and grew up loving country euphony; even so, he was besides careworn to the theatre and later stirred to New York, where he landed roles in deuce national touring productions. He later settled in Los Angeles, where he began playing the now-legendary alt-country hot spot the Palomino Club. With Dwight Yoakam producer Pete Anderson behind the boards, he recorded a track for the seminal compilation A Town South of Bakersfield, which helped him -- briefly -- res publica a record deal with CBS. He completed an album in 1989, just the label declined to release it; it last appeared o'er decade long time later on on an overseas label as Point of No Return.Undaunted, Lauderdale signed with the Bluewater euphony publication firm in Nashville, where his compositions set up immediate success in the contemporaneous res publica worldly concern. Additionally, he sang backup on records by Yoakam, Lucinda Williams, and Rosie Flores and toured with everyone from Freedy Johnston, Nick Lowe, and Hootie & the Blowfish to Johnny Cash and Merle Haggard. He earned another shot with Reprise and issued his debut album, Major planet of Love, in 1991, with production from Rodney Crowell and John Leventhal. The record album was greeted with stiff reviews by many critics, world Health Organization hailed Lauderdale as a major modern natural endowment. Still, it would be triplet days before he would release another record; he returned in 1994, now on Atlantic, and issued 2 acclaimed albums over the next iI old age in Pretty Close to the Truth and Every Second Counts. In 1996, he affected over to roots label Rounder's Upstart subsidiary for Persimmons, withal some other critical success. Hopping to BNA, Lauderdale released Whispering in 1998, then returned to the big league on RCA, issuing the somewhat slicker-sounding, more than commercial Forward Through It All in 1999. That same class, Lauderdale also took a detour into traditional bluegrass, recording the collaborative record album I Feel Like Singing Today with the legendary Ralph Stanley for Rebel. Lauderdale eventually establish a more than permanent home on Dualtone and debuted with 2000's The Other Sessions, a retrovert to hard-core state. 2002 brought iI projects: another album with Stanley, called Lost in the Lonesome Pines, and a country record called The Hummingbirds. Ever prolific, Lauderdale released Hold back Til Spring in 2003, Headed for the Hills in 2004, Bluegrass Region in 2006, and The Bluegrass Diaries in 2007. |
Coldplay tops Europe for seventh week
Thursday 7 August 2008
Tuesday 1 July 2008
Wednesday 25 June 2008
Quruli with Rip Slyme
Artist: Quruli with Rip Slyme
Genre(s):
Pop: Japan
Discography:
Juice
Year: 2006
Tracks: 2
Michael Nyman
Sunday 22 June 2008
Jim Jones and Juelz Santana
Artist: Jim Jones and Juelz Santana
Genre(s):
Rap: Hip-Hop
Discography:
Jim Jones Feat. Juelz Santana - Ambitionz Of A Gangsta
Year: 2004
Tracks: 26
Saturday 21 June 2008
The Forecast
Artist: The Forecast
Genre(s):
Rock
Discography:
Late Night Conversations
Year: 2005
Tracks: 10
Harry James
Friday 20 June 2008
What's on
ROCK/POPKiwi songstress Anna Coddington has released her lovely new album The Lake, so why not play fifteen shows around New Zealand to celebrate? From Wanaka to Auckland, she hits the road in June with her band which includes members of Dimmer, Trinity Roots and Opensouls. If you enjoyed recent albums by Bic Runga and Anika Moa, this is in a similar musical vein.Anna Coddington national tour - Classic Comedy Bar, Auckland, June 5, Flow, Hamilton, June 6; myspace.com/annacoddington for other datesFESTIVALThink back to your childhood, and the books that were read to you. Was Hairy McClary your favourite? Or something by Roald Dahl? These books create a whole world in the imagination of kids, and the people who create these worlds are here for the Storylines Festival. Children and parents can meet special international guests, and Kiwi icons such as Margaret Mahy and Joy Cowley. Storylines Festival various venues all over New Zealand - June 8-15, open day at Aotea Centre June 15, storylines.org.nz for details
DANCE/DJFrom a Grey Lynn bedroom in 1998, to Ponsonby Rd and Auckland-wide in 2008, George FM has come along way since it was switched on ten years ago. The station is having a ball this Friday to celebrate this ten-year milestone. Peter Urlich will sing with his lounge covers band, dance act House of Downtown will reform after a five-year hiatus to play live, and a clutch of stalwart DJs will spin tunes. George FM 10th Birthday Ball Pontoon -Westhaven Marina, June 6, iticket.co.nzMUSICALIt seems New Zealanders really do love the nightlife. Priscilla Queen of the Desert: The Musical is an absolute sensation. Playing at Auckland's Civic Theatre, 65,000 Kiwis will be heading along in the next month. Why? Well, the exhilarating soundtrack of hits such as I Will Survive and Shake Your Groove Thing combined with a thirty-strong cast, 500 costumes and a 10m bus probably have something to with it. Priscilla Queen Of The Desert: The Musical - Civic Theatre, Auckland, to July 6, tickets from the-edge.co.nzFESTIVALWhether you are a professional photographer or an amateur snapper who exhibits weekly on your Facebook page, there will something of interest to you in the Auckland Festival of Photography, on until June 22. There are 30 exhibitions so head to the website to find the ones you fancy. Aucklanders can enjoy everything from the Splore music festival photo competition to a touring festival of Iranian photography.Auckland Festival Of Photography - various venues, to June 22, photographyfestival.org.nz
DANCE/DJFrom a Grey Lynn bedroom in 1998, to Ponsonby Rd and Auckland-wide in 2008, George FM has come along way since it was switched on ten years ago. The station is having a ball this Friday to celebrate this ten-year milestone. Peter Urlich will sing with his lounge covers band, dance act House of Downtown will reform after a five-year hiatus to play live, and a clutch of stalwart DJs will spin tunes. George FM 10th Birthday Ball Pontoon -Westhaven Marina, June 6, iticket.co.nzMUSICALIt seems New Zealanders really do love the nightlife. Priscilla Queen of the Desert: The Musical is an absolute sensation. Playing at Auckland's Civic Theatre, 65,000 Kiwis will be heading along in the next month. Why? Well, the exhilarating soundtrack of hits such as I Will Survive and Shake Your Groove Thing combined with a thirty-strong cast, 500 costumes and a 10m bus probably have something to with it. Priscilla Queen Of The Desert: The Musical - Civic Theatre, Auckland, to July 6, tickets from the-edge.co.nzFESTIVALWhether you are a professional photographer or an amateur snapper who exhibits weekly on your Facebook page, there will something of interest to you in the Auckland Festival of Photography, on until June 22. There are 30 exhibitions so head to the website to find the ones you fancy. Aucklanders can enjoy everything from the Splore music festival photo competition to a touring festival of Iranian photography.Auckland Festival Of Photography - various venues, to June 22, photographyfestival.org.nz
Heartsdales
Artist: Heartsdales
Genre(s):
Pop: Japan
Rap: Hip-Hop
Folk
Discography:
Gonna Love
Year: 2006
Tracks: 5
Fantasy
Year: 2004
Tracks: 4
Sugar Shine
Year: 2003
Tracks: 18
CANDY POP feat. SOUL'd OUT
Year:
Tracks: 4
Antimatter
Everlost
Artist: Everlost
Genre(s):
Rock
Metal: Death,Black
Metal
Discography:
Noise Factory
Year: 2006
Tracks: 10
Bitterness Of The Triumph
Year: 2004
Tracks: 8
Suicidal Instincts
Year: 2002
Tracks: 6
Once best known for his term of office in the rap social unit House of Pain, Everlast successfully reinvented himself in 1998 with the best-selling Whitey Ford Sings the Blues, a for the most part acoustic, hip-hop-flavored endeavour in the genre-crossing cast of Beck. Born Erik Schrody, Everlast first surfaced in Los Angeles as a member of Ice-T's Rhyme Syndicate Cartel, issuance his debut album, Everlastingly Everlasting, in 1990. When the album failed to ascertain an audience, he formed House of Pain with Danny Boy and DJ Lethal; carving out an prototype which drew heavy on Everlast and Danny Boy's shared Irish inheritance, the triple managed to get the better of the stereotypes facing white rappers and scored a massive murder with their 1992 individual "Spring Around." Their self-titled debut LP besides went atomic number 78, only when follow-ups including 1994's Same as It Ever Was and 1996's Truth Crushed to Earth Shall Rise Again failed to repeat House of Pain's early succeeder, the group disbanded. Everlast then returned to his solo career, only while recording Whitey Ford Sings the Blues he suffered a massive cardiac nab stemming from a innate defect, resulting in heart shunt surgery and an unreal valve implant. Following his recovery, he completed the album, which appeared in the fall of 1998 to strong commercial-grade notices: hit the Top Ten, going atomic number 78, and launching the Top 40 individual "What It's Like." After coming into court on Santana's vaunted comeback album Supernatural, Everlast began exploit on a review with an eclectic group of guest artists. Titled Consume at Whitey's, the album was released in later 2000, and enjoyed critical notice even if it wasn't quite as succesful as Whitey Ford. Everlast then returned in 2004 with the dwight Lyman Moody, more song-driven White Trash Beautiful.
Bones Brigade
Artist: Bones Brigade
Genre(s):
Rock: Punk-Rock
Discography:
Older than Shit, Heavier than Time
Year: 2005
Tracks: 17
I Hate Myself When I'm Not Skateboarding
Year:
Tracks: 13
Leading the charge
Mario Biondi
Artist: Mario Biondi
Genre(s):
Jazz
Discography:
Handful Of Soul
Year: 2007
Tracks: 12
Italian jazz-soul vocalizer Mario Biondi was born of artistic stock in the Sicilian city of Catania. His great granddaddy was a respected painter, his gran a singer, and his father a popular ballad maker. Biondi american ginseng passim his childhood, first playacting in populace at historic period 12 in church, and presently singing in populace squares before hundreds of people. From there he competed in the Festival della Canzone Siciliana, taking third base place. Biondi's musical pursuits earned him the chance to perform aboard such Italian vocal greats as Califano, Bongusto, and Fiorello, as well as American legend Ray Charles. As word of his talent and acquirement got out, Biondi launch himself collaborating with groups like the Change, Mario Brothers, and Funky Company on recordings and tours. Given his powerful and unique vocalism, it was not long earlier Biondi was encouraged to pursue a solo career. Featuring material divine by American R&B artists like Lou Rawls, Luther Vandross, and Donny Hathaway, Biondi's debut criminal record was released in 2006 on the dress shop tag Family Affair. Fistful of Soul featured the individual "This Is What You Are," which went instantly into heavy rotary motion throughout Italy and the U.K. A year by and by Biondi performed the song at the important Sanremo Festival in Italy, bolstering the record's popularity and helping to advertize it into Billboard's European Top 100 chart.
Will Smith's Daughter Not Fussed By Box Office Battle
Latest: Will Smith's daughter Willow Smith doesn't mind if her new film is beaten at the box office by her father's new release Hancock - as long as he continues to spoil her with "nice things". The father and daughter duo are set to battle it out on the big screen when Smith's Hancock and seven-year-old Willow's film Kit Kittredge: An American Girl hit U.S. cinemas on 2 July . But the Men In Black star admits his little girl isn't too fussed if she loses out. He says, "I just told her, 'Sweetheart, daddy loves you - but I've got to stop you at the box office.' She was like, 'Well daddy, you get us a lot of nice things, so you do what you have to do.'"
See Also
See Also
Stillste Stund
Artist: Stillste Stund
Genre(s):
Electronic
Discography:
Ursprung Paradoxon
Year: 2001
Tracks: 12
Ein Mensch,ein Ding,ein Traum
Year: 2000
Tracks: 14
Xentrix
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